Molecular Partners (NASDAQ:MOLN – Get Free Report) and enGene (NASDAQ:ENGN – Get Free Report) are both small-cap medical companies, but which is the better investment? We will compare the two businesses based on the strength of their risk, analyst recommendations, profitability, dividends, institutional ownership, earnings and valuation.
Volatility & Risk
Molecular Partners has a beta of 1.06, indicating that its stock price is 6% more volatile than the S&P 500. Comparatively, enGene has a beta of -0.65, indicating that its stock price is 165% less volatile than the S&P 500.
Analyst Ratings
This is a summary of recent recommendations and price targets for Molecular Partners and enGene, as provided by MarketBeat.
| Sell Ratings | Hold Ratings | Buy Ratings | Strong Buy Ratings | Rating Score | |
| Molecular Partners | 0 | 0 | 0 | 1 | 4.00 |
| enGene | 0 | 1 | 8 | 1 | 3.00 |
Institutional and Insider Ownership
26.5% of Molecular Partners shares are held by institutional investors. Comparatively, 64.2% of enGene shares are held by institutional investors. 5.9% of Molecular Partners shares are held by insiders. Comparatively, 13.7% of enGene shares are held by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock is poised for long-term growth.
Profitability
This table compares Molecular Partners and enGene’s net margins, return on equity and return on assets.
| Net Margins | Return on Equity | Return on Assets | |
| Molecular Partners | -1,043.01% | -39.31% | -35.46% |
| enGene | N/A | -16.69% | -14.27% |
Earnings and Valuation
This table compares Molecular Partners and enGene”s revenue, earnings per share and valuation.
| Gross Revenue | Price/Sales Ratio | Net Income | Earnings Per Share | Price/Earnings Ratio | |
| Molecular Partners | $6.00 million | 32.82 | -$69.04 million | ($2.15) | -2.27 |
| enGene | N/A | N/A | -$55.14 million | ($0.58) | -10.52 |
enGene has lower revenue, but higher earnings than Molecular Partners. enGene is trading at a lower price-to-earnings ratio than Molecular Partners, indicating that it is currently the more affordable of the two stocks.
Summary
enGene beats Molecular Partners on 9 of the 13 factors compared between the two stocks.
About Molecular Partners
Molecular Partners AG, a clinical-stage biotechnology company, develops designed ankyrin repeat proteins therapeutics for the treatment of oncology and virology diseases in Switzerland. The company develops MP0317, a CD40 agonist designed to activate immune cells within the tumor microenvironment by anchoring to fibroblast activation protein that is in Phase I clinical trial; and MP0533, a novel tetra-specific T cell-engaging DARPin for acute myeloid leukemia. It also develops Switch-DARPin platform, a multispecific cKIT x CD16a x CD47 Switch-DARPin program for targeted and conditional immune cell activation; and Radio-DARPin Therapy (RDT) platform, a delivery system for effective and selective delivery of radioactive payloads to solid tumors. It has license and research collaboration agreements with Novartis Pharma AG to develop DARPin-conjugated radioligand therapies; and collaboration agreement with Orano Med SAS to develop novel Radio-DARPin therapeutics. Molecular Partners AG was incorporated in 2004 and is headquartered in Schlieren, Switzerland.
About enGene
enGene Holdings Inc., through its subsidiary enGene, Inc., operates as a clinical-stage biotechnology company that develops genetic medicines through the delivery of therapeutics to mucosal tissues and other organs. Its lead product candidate is EG-70 (detalimogene voraplasmid), which is a non-viral immunotherapy to treat non-muscle invasive bladder cancer patients with carcinoma-in-situ (Cis), who are unresponsive to treatment with Bacillus Calmette-Guérin. The company was founded in 2023 and is based in Saint-Laurent, Canada.
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